RNA Details
Disease Name
pulmonary arterial hypertension
Tissue
lung
RNA Symbol
Edn1
RNA ID
RNA Type
mRNA
Alteration Pattern
histone acetylation
Species
rattus norvegicus
Detection Methods
Immunohistochemistry; qRT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR
Year
2013
Function
"The maternal nutrient restriction increased the histone acetylation and hypoxia inducible factor-1a (HIF-1a) binding levels in the ET-1 gene promoter of PVEC in IUGR newborn rats, and continued up to 6 weeks after birth. These epigenetic changes could result in an IUGR rat being highly sensitive to hypoxia later in life, causing more significant PAH or pulmonary vascular remodeling."